Targeting VEGF signalling via the neuropilin co-receptor
نویسندگان
چکیده
منابع مشابه
Neuropilin signalling in angiogenesis.
VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Ther...
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Using human MSCs (mesenchymal stem cells) lacking VEGF (vascular endothelial growth factor) receptors, we show that the pro-angiogenic receptor neuropilin-1 associates with phosphorylated PDGFRs [PDGF (platelet-derived growth factor) receptors], thereby regulating cell signalling, migration, proliferation and network assembly. Neuropilin-1 co-immunoprecipitated and co-localized with phosphoryla...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2013
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2012.11.013